[Solved] Cannot open .xlsx file, xlrd.biffh.XLRDError: Excel xlsx file; not supported

The reason is that xlrd has recently been updated to version 2.0.1 and only supports .xls files. So it x1 = xlrd.open_workbook("data.xlsx")will report an error.

You can install the old version of xlrd and run it in cmd:
it is recommended to uninstall the new version directly and download the old version of xlrd

pip uninstall xlrd
pip install xlrd==1.2.0

You can also use openpyxl instead of xlrd to open .xlsx files:


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