At first, there was no problem with using rdkit. When deep Chem is installed later, this error will be reported,

DLL load failed while importing rdBase

The rdkit package may be damaged, so you can reinstall the rdkit. The installation code is as follows

conda install -c rdkit rdkit

However, it is recommended to install deepchem in a separate virtual environment, it will affect many of the previously installed packages, such as numpy and so on